Connection of parameters of hormonal status, expression degree of menopausal disorders and psychoemotional state in perimenopausal women

Analysis of 25 women of perimenopausal period was conducted in order to reveal their hormonal
parameters, the degree of severity of menopausal disorders and psycho-emotional state.
Women with anxiety and depressive disorders had more severe course of menopausal syndrome
and estradiol level in their blood was signifi cantly lower than in blood of patients without the psycho-
emotional disorders. The interrelation of the presence of psycho-emotional disorders (PED), the
level of estradiol and modifi ed menopausal index was dependent on the duration of menopause.
For women in perimenopause confi rmed diagnosis of PED and estradiol levels were associated with
the number of hot fl ashes and degree of their severity.Strong dependence was revealed between PED and the increase of prolactin concentration in
blood. Patients with PED showed a decrease in concentration of serotonin in blood in the dynamic
observation, which was associated with decrease of estradiol level, which confi rms the positive rate
of correlation of dynamic indices of these hormones.